Launch from the Baikonur Cosmodrome; landing with Soyuz 31 spacecraft 140 km southeast of Dzheskasgan.

Following a one day solo flight the Soyuz docked with Salyut 6 on 16.06.1978. The cosmonauts became the 2nd resident crew of Salyut 6. After activating the stations life systems (air regenerators and thermal regulation system, the water recycling system), they performed maintenance on the station's airlock, installed equipment and tested the station's Kaskad orientation system. During the mission, the cosmonauts conducted numerous scientific experiments in the fields of medicine and materials science.

The resident crew was visited by Interkosmos flights of Soyuz 30 (28.06.1978) and Soyuz 31 (26.08.1978). The cargo spacecrafts Progress 2 - 4 delivered water, food, fuel and equipment and turned back trash and no more needed equipment.

EVA on 29.07.1978 by both cosmonauts to retrieve detectors and materials samples launched attached to the Salyut 6 hull (2h 05m). On 07.09.1978 the crew also relocated the Soyuz 31 spacecraft from the aft port of the station to the front port of the station for the first time. Later on this became a routine procedure.

The crew set a new spaceflight record.