Launch from Cape Canaveral (KSC). The launch was delayed for the first time in the Apollo history for about 40 minutes due to bad weather. The landing was near of Samoa Island in the Pacific Ocean.

Third manned moon landing; landing site: Fra Mauro.

Two EVAs by Shepard and Mitchell. In the first EVA (4h 48m) they deployed the TV, S-band antenna, the American flag, and the Solar Wind Composition experiment. Other work were to take photos from the LM (named Antares), the lunar surface and the experiments and deploying the Apollo lunar surface experiments package (ALSEP) and the laser-ranging retroreflector. The also performed a seismic experiment. In the second EVA (4h 35m) they used for the first time the Modular Equipment Transporter (MET), a handcart to transport lunar rocks and samples, but it had also photographic equipment, tools, and a lunar portable magnetometer. Both men performed a geology traverse toward the rim of Cone Crater. At least Commander Shepard became the first man to golf on the lunar surface. He played with an original golf ball and a shovel, the drive was 366 m long. All in all 43 kg of material were gathered.

During that time astronaut Roosa, orbiting the moon in the CSM Kitty Hawk, took astronomy and lunar photos, including photos of the proposed Descartes landing site for Apollo 16.

The reentry was without any problems and they came down about 7 kilometers far from the recovery ship "USS New Orleans".